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Michael Skubala makes one change from the side that defeated Peterborough United 5-2 last time out.
Jack Moylan comes back into the side, in place of Ryley Towler who is on the bench.
Head coach Michael Skubala said: “"Jack Moylan is chomping at the bit to come in and is ready to go. We're making a small tweak in formation, but one which we think allows us to hurt them.
“Luton are a strong team, who have had a strong home record of late, so we know that we’ll have to be at our best to get the result we want.”
Imps: Wickens, Darikwa, Reach, Hackett, Moylan, McGrandles, Bradley, Street, Hamer, Varfolomeev, Draper.
Subs: Jeacock, Pardington, Montsma, Towler, Ring, Jefferies, Okewoye.