Michael Skubala makes one change to the side that defeated Stevenage at the LNER Stadium last Saturday.
Ryley Towler comes into the side in place of Adam Reach, who misses out due to an ankle injury.
Lewis Montsma and Dexter Lembikisa are named on the bench.
Skubala said: "It's always a competitive game at Orient, they've scored a lot of goals but have conceded a few as well.
"Adam Reach has been great for us, but went over on an ankle in the last bit of training on Friday. Ryley has been fantastic and at times like this we rely on our squad and we're going to need everybody this season."
Imps: Wickens, Darikwa, Towler, Hackett, Bayliss, McGrandles, Bradley, Street, House, Hamer, Draper.
Subs: Pardington, Montsma, Collins, Okoronkwo, Obikwu, Lembikisa, Varfolomeev.