Sam Clucas was handed his first Imps start since returning to the club in January - 5,617 days after his last appearance for City.
The 34-year-old midfielder, who featured in one Johnstone's Paint Trophy game against Darlington on September 1 2009, ended his wait for a second City appearance when selected to start at Leyton Orient.
Lewis Montsma, Dom Jefferies, Jovon Makama and Ben House also come into the starting XI. Tendayi Darikwa is left out of the squad having become a father again.
Imps head coach Michael Skubala said: “Orient are in great form and have started well in games, they are aggressive and press high so we’ve got to be strong and ready to make our moments count.
“We think this is a good game for Sam Clucas to come in alongside Conor McGrandles in the centre of midfield.
“Our two nines are going to have to work hard to put them under pressure. We will try and stretch the line.”
Imps: Jeacock, Montsma, Hackett, McGrandles, O'Connor (c), Jefferies, House, Roughan, Clucas, Makama, Draper. Subs: Wickens, Jackson, Bayliss, Hamilton, Ring, Collins, Okoro.