Head coach Michael Skubala makes two changes to the side that defeated Barnsley at the LNER Stadium in midweek.
Ryley Towler and Rob Street come into the side, with Dom Jefferies and Freddie Draper taking up places on the bench.
Skubala said: "We want to be aggressive in the right moments, all our forwards have different profiles and we think Rob suits what we want to do with our gameplan.
"Blackpool FC are a big club in this league and are in a false position, the new manager has turned them around which you've seen in their most recent games - but the lads are all excited by the challenge and ready to put in a performance."
Imps: Wickens, Darikwa, Reach, Towler, Hackett, Bayliss, Moylan, McGrandles, Bradley, Street, Hamer.
Subs: Jeacock, Ring, Jefferies, Okoronkwo, Obikwu, Varfolomeev, Draper.