City's trip to Rotherham United scheduled for Wednesday has been postponed after the Imps reluctantly informed the EFL they would not be able to fulfil the fixture due to a number of Covid-19 cases in their squad.
Chief executive Liam Scully said: "We were able to fulfil Boxing Day's fixture despite having some players test positive for Covid-19, unfortunately further positive tests on Tuesday mean we are now not able to fulfil Wednesday's fixture.
"We will continue to train and prepare as normal for Saturday's game at Ipswich Town in the hope that players returning to the group will allow us to meet the criteria to play. We'll follow strict protocols at the Elite Performance Centre to minimise the risk of catching or spreading Covid-19.
"We commit to communicating with supporters, Ipswich and the EFL as quickly and clearly as possible over the coming days."
In light of the increased transmission rate of the Omicron variant, the EFL will now review the circumstances surrounding the postponement.
In addition it will assist affected clubs throughout this challenging period to help them mitigate against the risk of infection amongst players and staff, while ensuring their obligations to the EFL regulations are maintained.
A rearranged date for the fixture will be confirmed in due course.